Slow to no response

I have an older box running Win2k with CF 5.0 SP 4 Enterprise, JRun 3.1 and MDAC 2.71.9030.9. Its my last box still running 5 that I was leaving alone for all my hosting customers who are running old apps and aren't willing to update. Over the past few months the box has degraded to ridiculous slowness when responding to ColdFusion requests. The non CF sites aren't having problems. End users regularly receive the following error when requesting a page:

ODBC Error Code = S1000 (General error)

[Microsoft][ODBC Microsoft Access Driver] Could not update; currently locked by user 'admin' on machine 'ROSEQUARTZ'.

Rosequartz is the name of the server.

When I look at the server.log I see lots of errors like:

"Error","832","12/05/06","15:00:50",,"Windows NT error number 109 occurred."
"Error","832","12/05/06","15:00:50",,"Error number 232 occurred attempting to close connection to web server."
"Error","832","12/05/06","15:00:50",,"Windows NT error number 232 occurred."
"Error","604","12/05/06","15:00:52",,"Error number 232 occurred while attempting to write the reply to the web server."
"Error","604","12/05/06","15:00:52",,"Windows NT error number 232 occurred."
"Error","604","12/05/06","15:00:52",,"Error number 232 occurred attempting to close connection to web server."
"Error","604","12/05/06","15:00:52",,"Windows NT error number 232 occurred."
"Error","604","12/05/06","15:00:53",,"Unable to write reply -- client browser stopped waiting for request. "
"Error","604","12/05/06","15:00:53",,"Windows NT error number 109 occurred."
"Error","604","12/05/06","15:00:53",,"Error number 232 occurred attempting to close connection to web server."

Rebooting does not even temporarily speed up the response rate. We have checked Windows, IIS, and everything else on this box and nothing appears to have a problem. Has anyone experienced something like this or have any advice?

Thanks,
J.