DW 8 Crashing on updating the site cache

This is a site that I've been working on, on and off, for a year or more and suddenly in the past week or so DW has been hanging whenever I try and load this site. It seems to do it when updating the site cache. It doesn't crash exactly, but will hang on the splash screen, and won't advance beyond that point. I've reinstalled DW, removed all extensions, deleted the Configuration folder, but it keeps coming back. I've discovered that if I copy all the files in that folder somewhere else, load the site, and then copy them all back, it will load; but obviously this isn't a workable solution. I don't know WHICH file is causing it to hang; I've tried removing only the file that it seems to hang on, but then it hangs on a different one (and so on).

Any suggestions on how to resolve this?