I did use Foundation to create sites a few years ago, in fact my own website was built using version 4 of the framework.
As with the likes of Bootstrap, the framework consists of CSS and JS files and the markup (HTML) is left to the user, albeit with the assistance of the many examples. The best way to use the framework is to use the SCSS files which can be compiled within the current version of Dreamweaver. Together with the superior markup facilities, this makes Dreamweaver an exceptional tool for the development of Foundation projects.
I do not know much about Handlebars, I use my own PHP template engine which is very simple and robust.
To have Real-time preview work in Dreamweaver, you need to setup a site
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