"Save" & insert snippet greyed out with framesets

[Topic edited for clarity.]

Using DW 19.0.1 build 11212

First,

Only on certain files, the "save" option (under File) is greyed out, I cannot ctrl-S.  I can exit DW and it asks if I want to save the changes before exiting.  I choose yes, it works, but I cannot save it normally.  This isn't on every file, only on certain ones.

Secondly, on the same files, I am unable to insert a snippet.  If I double-click on the snippet - Nothing.  If I right-click, "insert" is greyed out.

I've deleted the cache per other instructions I've found here but to no avail.

Any pro tips for this?

Thanks,

-=Rob=-