Acrobat Pro DC - There was an error opening this document. The file is already open or in use

[BWM80128]

I am using Acrobat Pro DC 20.006.20042 on a Windows 10 PC.

When I try to open a PDF from a website, I receive the dialog box asking me if I want to Open or Save the file. When I choose Open, Acrobat will open to the Recent files page and display the error "There was a problem opening this file.  The file is already open or in use by another application."  If I choose Save File from the webpage, save the file locally and then open the PDF files there is no problem.

This problem began within the last few days or weeks and I cannot find a fix in the Community.

I have tried the following steps to resolve:

1. Cleared temp files from windows and browser cache

2. Rebooted computer

3. Signed out of Adobe account in Acrobat Pro DC, rebooted and logged back into account

4. Tried the Help>Repair Installation from the Acrobat menu

[Merlin T · Accepted solution]

I was having this issue too and come to find out, my McAfee WebAdvisor Add-on was causing the issue.  I guess it grabs the file for inspection, therefore, not allowing Adobe Reader app to open it from the browser.  When I disabled this Add-on, the file opens from within Fire Fox.  I'm not sure how to get this to work with this Add-on enabled.

[defaultohsxnm3utnwb]

This!! My problem is finally solved.  I had this same issue but in Chrome. The McAfee web advisor was blocking the PDF from opening. Just for reference, I was getting the "this file is already open or in use by another application". Check your anti-virus settings in your internet browser! 

Chrome Settings > Extensions > Disable McAfee. My PDF opened immediately. 

[Sophia22010757ygrl · Accepted solution]

Yes - Its the Mcafee extention in firefox that causes it! Thank you! Now I disabled it, it seems to work fine 🙂

[BRay1623]

Thank You!!! Was definitely my McAfee ectension! I disable it and pdf opened up perfectly!

Thanks Again for sharing

[BRay1623]

Spell check !!

Extension :0)

[John5D66]

I worked with McAfee on this for 3 hours.  
Long story short, we uninstalled "WebAdvisor by McAfee" and reinstalled it.  Seems to work now.  Something was corrupted in that application.  

Look for it on your program list in the "W's".  It's not grouped with the other two McAfee apps.  

[FengShuiWizardess]

Thank you for your persistence in working with McAfee!

[NetFu]

Well, I'm just chiming in to say that we got this error and it was definitely not caused by McAfee.  Removed the Webadvisor software, still had the problem.

[Raaz28977132geek]

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