It goes without saying that some fonts are much easier to read than others. When choosing fonts for storefront signage, for example, the best fonts are usually clean, bold and uncomplicated by fleurishes or calligraphic reliefs. And the best fonts for print may not be the right choice for viewing on a digital screen. So it's 1 part art & science and 2 parts common sense.
Nancy O'Shea, Product User & Community Expert Alt-Web Design & Publishing ~ Web : Print : Graphics : Media