JRun Connector, CF9, IIS6 and jrun_iis6_wildcard.dll

We are running CF9 in distributed mode on Windows 2003 Enterprise R2 64-bit.  When I configured the JRun connector on the multiple web sites that connect to the remote CF9 clustered server instances, I also do the mappings with "Check if files exists" for the appropriate file extensions, e.g. .cfm, .cfml, .cfc, etc.   Six years ago, when we had only ColdFusion on the remote web servers, I also ensured that the "jrun_iis6_wildcard.dll" was set to "Check if file exists".  Now, however, as some .NET web apps have appeared on the remote web servers, the "Check if file exists" on the "jrun_iis6_wildcard.dll" causes the .NET web applications to fail until we deselect that option on the specific web application folder for the .NET app.

My question is this:  if I deselect the "Check if file exists" for the entire web site's "jrun_iis6_wildcard.dll" (and not just the specific .NET apps), will there be any adverse impact on the ColdFusion web applications?  Or, is the individual mapping of the .cfm, .cfml, .cfc, etc. to "Check if file exists" sufficient?

Thanks,

Scott