John, this is a brilliant idea. I don't know how to implement it, but I love the idea. I have outlined the reasons for the need for different graphics in reply to a different post, but the quick version is the visibility of a precise color of yellow needed for color lines (railway track maps). They show up great on files intended for viewing on a tablet or screen, but are difficult to see on bright white paper; and stroked lines that look great in print show up almost black on screen. So my next question, as related to your suggestion, would be how do I go about implementing it? I use only about 10 graphic files for 57 pages (vertical-master, vertical-print; horizontal-master, horizontal-print, etc, where print is the same as master except yellow lines have a 0.1 pt stroke). I have placed the files in a precise location on each page, and overlayed InDesign text on top of it. It's all on one layer at the moment; text and graphics, etc. Would it be possible to move all the graphics from the current single layer to their own layer, duplicate that layer, and then re-link the files on that duplicated layer to the print variants? Or am I overthinking this somehow?
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