Acrobat Reader Freezes on opening PDF

We've got about 150 workstations, last week, a small number of users from different departments and offices started reporting issues of Acrobat Reader freezing when opening PDFs.

We've tried reinstalling the software, including using the acrobat cleaner tool however it doesn't fix the issue. The reinstall has been tried through two different methods - via Chocolately and manually after downloading the installer from Adobe's website. However neither has corrected the issue.

The impacted workstations are a mix of Windows 10 Enterprise, and Windows 11 Enterprise with no updates pending, Acrobat is a mix of the previous version, and the current (23.006.20320).

I've tried pushing out a registry entry via Group Policy to disable protected mode, and while it does indeed disable protected mode, it doesn't prevent it from the program locking up.

Is anyone able to offer any advice or recommendations?