Adobe Reader Send Email... Using Webmail (not client) issues with Office365

Hopefully someone has some insights on this issue.  We have a PDF form that has a submit button to forward completed forms to supervisor.  The backend stuff works great.  For staff with Outlook client it works.  For those staff without Outlook we have gone ahead and set up the webmail (add account) preference and this is where the issue arises.

Default: incoming: outlook.office365.com, advanced SSL 993

outgoing: smtp.office365.com, advanced TLS 587 (although I have tried 25 default as well with Security and without)

After filling out the form, clicking submit, the progress bar begins and after trying to authenticate it fails and requests your information again.  Type it (making sure it is correct) and again the progress bar show preparing to send then quickly the progress bar completes and window disappears with no sign of error.

Of course, if we do these same steps on same computer with local user signed in (not a domain account) the same procedure yields better results.  Clicking submit goes through the progress than gives you window to complete transaction in ones webmail as the draft has been created.  Sure enough you check your online draft folder and the message is sitting there waiting for one to add the supervisor email address.

Notes: 

• These staff will not be getting Outlook; that would solve my issue right there   They use Office 365 online and the client is not an option.  Also note that the issue happens when the user is logged onto their domain account (2008R2 domain).
• This same setup with Gmail instead of Office 365 works like a charm for both local/domain users, haven't tried Yahoo.

Thoughts before finally seeing the difference between domain/local users on same machines:

• Originally thought it might have been app, but multiple workstations work same way.  Even after uninstalling and reinstalling.
• Then thought it could be ports being opened/closed on firewall.  Tried different ports and security options.

Of course today is when I decided to try on a Mac I have, with same IP settings in our network and it worked.  So then proceeded to test the local user which is when I found it works fine except for domain user.

I am not aware of any GPO's that could prevent this?  Does anyone know where I can check? At this point somewhat lost in the weeds figuring out how to troubleshoot and logically reach next step.