Hello @ERINMCLEAN
I hope you are doing well, and sorry for the trouble you had. Thanks for sharing all the additional details.
The key detail is that PDFs open locally, and attachments from your other Outlook accounts work. Since **Save As doesn’t produce a saved PDF**, this looks more like an issue retrieving or saving attachments for that one account in Outlook than a problem opening PDFs in Acrobat.
Could you try opening the affected mailbox in Outlook on the web and downloading one of those attachments there? If the downloaded file opens from Finder, that would help isolate the issue to Outlook for Mac’s handling of that account. If it also fails on the web, the mail provider or your organization’s administrator may need to check that mailbox’s attachment access.
Fixes:
- Reset that one account's cache in Outlook for Mac. Make sure you're online, then go to Tools > Accounts, select the affected account, and choose Manage > Reset Account. That re-downloads the account from the server (note: anything stored only locally for that account, not synced to the server, is removed, so back that up first). If Reset Account isn't offered or doesn't help, remove the account (Manage > Remove Account) and add it back (+ Add Account), removing it from Outlook does not delete the mailbox.
- If it also failed on the web and this is a work/managed account, it's server-side, and your IT team is the fix. Ask them to check whether Microsoft Defender "Safe Attachments" (its Dynamic Delivery mode replaces attachments with placeholders until scanning finishes), quarantine, a mail-security gateway, or message encryption is applied to that mailbox.
- Setting Acrobat as the default PDF app won't fix this, since your other accounts work, so skip that.
To narrow it down, could you tell us:
- What type is the affected account, Microsoft 365/Exchange (work or school), Outlook.com, Gmail, iCloud, Yahoo, or other IMAP?
- Is it a work/managed account?
- Does the same attachment open in Outlook on the web for that account?
- Are you on the current Outlook for Mac or Legacy Outlook (check the Outlook menu / Help)?
- Any error message, and your macOS + Outlook versions (Outlook > About Outlook)?
You can also try the suggestions from this article: https://helpx.adobe.com/acrobat/kb/cant-open-pdf.html
I hope this helps, and please reach out if you have any questions or need any assistance.
Regards,
Anand Sri.