RDS 2016 Adobe Reader access denied

I have found many posts pertaining to this same issue the past. I have users who are using a 2016 Remote Desktop Session Host server, utilizing profile disks. Often users will get the Access denied error the first few times they attempt to open a PDF document. 

This happens if opened directly through Outlook or if saved Locally. Eventually they will be able to open the document without making any changes.

I have all security disabled within Adobe Reader..

And we are on the most updated version of the application.

This is becoming frustrating to the users to the point they want to use an alternative application for PDFs.

Are there any new updats to come out that may address this issue?

Thanks!

Ian