Unable to open Reader or open PDFs from outlook

I am unable to open Reader on Win 11.  PDFs from Outlook also will not open.  I have searched high and low for a solution, but none have worked.  Reinstalling, cleaner utility, deleting left over install files, compatibility mode, Outlook Trust settings, and so on.

I can launch it as Admin by selecting ‘Open with Protection mode disabled’.  But if I turn the feature off in Readers preferences it still does not open unless I launch it using admin.

Any ideas?