Hello,
Thank you for reporting this. If this occurs after making a change in the graph, such as adjusting a parameter value, then the unresponsiveness is likely caused by the invalidation process. Invalidation involves traveling the graph and assessing everything that needs to be recomputed. If a graph uses a lot of subgraphs, with multiple levels of depth, then that process can take a long time.
We are actively working on making this process more efficient and improve Designer's responsiveness when working in large projects.
In the meantime, you can reduce the invalidation time by limiting the portion of a project that needs to be recomputed when making a change. For instance, do not view a main graph's outputs in the 3D View or 2D View when working on a subgraph. I understand this is not ideal, this issue is impacting our own technical artists as well.
Also, feel free to share your project with me so I can assess what optimisations can be made to reduce invalidation times
Thank you for your patience.