After a computer update, and many problems now solved, I cannot get sound out of Adobe Audition. I can record, but it's all in mono, and hearing as I play - mono, and only if I turn up the USB/Direct knob on my interface.

Ok, couple months ago, the mandatory computer update happened.  Adobe Audition would not open.  After 3 computer techs, and an online “Answer guy”, and after uninstalling and installing drivers for M Audio 192/6 several times, I can open the program, but I’m not getting any sound out of the normal M Audio settings on the interface.  I can hear whatever I’m inputting, and I can record it, but it comes out in mono.  If I turn the USB/Direct knob off, there is no sound.  If I open a previously recorded session, everything appears normal - everything plays, pannings are there, stereo’d tracks are stereo.  So, no sound unless I turn up the USB/Direct knob, and anything I listen to or record will be mono.  I’ve exhaustingly looked at the Hardware setup, everything looks normal, same for the computer sound and speaker settings - everything looks right.  This is after about 3 years and hundreds of sessions without problems.  Only after the update did all this bs start.