How would you lay out this kind of model with size and resolution in mind

I am currently making a large hospital campus which will be a scenery for msfs2020/-2024. I have made the building complex in Sketchup while doing the UV-layout in Blender before texturing in Substance painter.

I am recieving feedback that my projects are large in size, mainly due to the texture files. I have in the previous project set up the building with many different sized textures sets, but they have been too many resulting in a large sized project. With the current project I am keeping the number of texture sets lower to reduce size, but that results in larger UV’s and blurry textures.

My question is: Creating a large building complex, how would you go about solving any resolution issue while also considering file size and draw calls?

Sketchup model with predefined materials as texture sets.

The assigned materials and it’s UV layout

2k brick textures assigned to the texture set in substance painter.