defaultumk,
As I (mis)understand your enquiry, the actual appearance in an actual (flip)book depends entirely on the use of a fully or partially transparent sheet (which may be by degree or extent), so it is completely independent on the way you create the artwork/background in AI/PDF/INDD. In connexion with normal printing, both transparency and white simply mean no ink.
So to get the desired effect in an actual (flip)book you simply have to use a transparent sheet, corresponding to the well known insertion of different sheets for glossy photo pages.
To (more or less) see what it will look like, you can do what Ton said to fake it. If you have a printer that can print on a transparent sheet, you can print the top page on that (with or without something on the other side) and place it on the next page on (normal) paper, and then you can work on the fake to make it look the same, with or without blurring/fading/whatever.