Can I delete very old com.adobe files?

Mac OS 12.5.1, PS 23.5.0.  A few days ago I deleted the PS Preferences to try to resolve a strange issue, and while I was in the folder [username]/Library/Preferences/ I fuond a number of very old files starting with com.adobe.  Some go back 10 years, presumably from updating to new computers at least twice over that time.  I am only using the latest versions of Photoshop and Lightroom.  Is it safe to delete these com.abobe files that are more then a year old, or is it possible some may still be doing something with newer versions?  Some are for programs I haven't used in years, things like a lockfile and plist for Bridge4...