Changing the numbers in the text to a different font via script in photohsop

Changing just part of a line is extremely difficult, it requires custom scripting.

This sample script separates a text layer at a return character and formats. You would have to customize it to select and send only number characters which may not be easy. I do not have time to modify it but the script is Apache-licensed so modify it as much as you want.

/*
Utility PS Scripts created by David M. Converse ©2018-21

This script replaces text and sets styling

Last modified 6/2/2021

Licensed under the Apache License, Version 2.0 (the "License");
you may not use this file except in compliance with the License.
You may obtain a copy of the License at

    http://www.apache.org/licenses/LICENSE-2.0

Unless required by applicable law or agreed to in writing, software
distributed under the License is distributed on an "AS IS" BASIS,
WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
See the License for the specific language governing permissions and
limitations under the License.
*/
#target photoshop

layerUpdate();

function setFormatting(start, end, fontName, fontStyle, fontSize){ //format text per input
    var idsetd = app.charIDToTypeID('setd');
    var action = new ActionDescriptor();
    var idnull = app.charIDToTypeID('null');
    var reference = new ActionReference();
    var idTxLr = app.charIDToTypeID('TxLr');
    var idOrdn = app.charIDToTypeID('Ordn');
    var idTrgt = app.charIDToTypeID('Trgt');
    reference.putEnumerated(idTxLr, idOrdn, idTrgt);
    action.putReference(idnull, reference);
    var idT = app.charIDToTypeID('T   ');
    var textAction = new ActionDescriptor();
    var idTxtt = app.charIDToTypeID('Txtt');
    var actionList = new ActionList();
    var textRange = new ActionDescriptor();
    var idFrom = app.charIDToTypeID('From');
    textRange.putInteger(idFrom, start);
    textRange.putInteger(idT, end);
    var idTxtS = app.charIDToTypeID('TxtS');
    var formatting = new ActionDescriptor();
    var idFntN = app.charIDToTypeID('FntN');
    formatting.putString(idFntN, fontName);
    var idFntS = app.charIDToTypeID('FntS');
    formatting.putString(idFntS, fontStyle);
    var idSz = app.charIDToTypeID('Sz  ');
    var idPnt = app.charIDToTypeID('#Pnt');
    formatting.putUnitDouble(idSz, idPnt, fontSize);
    textRange.putObject(idTxtS, idTxtS, formatting);
    actionList.putObject(idTxtt, textRange);
    textAction.putList(idTxtt, actionList);
    action.putObject(idT, idTxLr, textAction);
    app.executeAction(idsetd, action, DialogModes.NO);
	}

function layerUpdate(){
    //sample values
        var size1 = 96
        var size2 = 42;
        var font1 = 'Calibri';
        var style1 = 'bold';
        var texth = 220;
        var textw = 460;
    
    if(documents.length > 0){
        var originalDialogMode = app.displayDialogs;
        app.displayDialogs = DialogModes.ERROR;
        var originalRulerUnits = preferences.rulerUnits;
        var j = 0;
        try{
            var docRef = activeDocument;
            preferences.rulerUnits = Units.POINTS;
            var m = 0;
            for(var i = 0; i < docRef.artLayers.length; i++){
                var LayerRef = docRef.artLayers[i];
                if(LayerRef.kind == LayerKind.TEXT){
                    var TextRef = LayerRef.textItem;
                    TextRef.textComposer = TextComposer.ADOBESINGLELINE;
                    var layerText = TextRef.contents;
                    //can iterate through multiple find/replace pairs
                    var newText = layerText.replace('old', 'new');
                    newText = newText.replace('old-1', 'new-1');
                    newText = newText.replace('old-2', 'new-2');
                    if(newText != layerText){
                        j = i;
                        TextRef.contents = newText;
                        if(TextRef.size == size1){
                            TextRef.size = size2;
                            TextRef.font = font1;
                            TextRef.useAutoLeading = false;
                            TextRef.leading = size2;
                            var l = TextRef.contents.split(/\r/);
                            docRef.activeLayer = LayerRef;
                            setFormatting(0, l[0].length, font1, style1, size1); //send to formatting function
                            preferences.rulerUnits = Units.PIXELS;
                            if(TextRef.kind == TextType.PARAGRAPHTEXT){
                                TextRef.height = texth;
                                TextRef.width = textw;
                                }
                            preferences.rulerUnits = Units.POINTS;
                            break;
                            }
                        }
                    }
                }
            }
        catch(e){
            alert(e + '  ' + e.line);
            preferences.rulerUnits = originalRulerUnits;
            app.displayDialogs = originalDialogMode;
            return;
            }
        preferences.rulerUnits = originalRulerUnits;
        app.displayDialogs = originalDialogMode;
        }
    else{
        alert('You must have a document open to run this script.');
        return;
        }
    }