Yes, I restarted it when changing the Graphics Processor setting, and when deactivating the Technology Previews setting as well. And I tried the Technology Previews option with and without the Graphics Processor activated.
I get artefacts when transfrming with Onion Skin, but they disappear on confirming.
What have you done for all-purpose trouble-shooting so far?
Restoring Preferences after making sure all customized presets like Actions, Patterns, Brushes etc. have been saved might be a good starting point:
https://helpx.adobe.com/photoshop/using/preferences.html
https://helpx.adobe.com/photoshop/kb/basic-trouble-shooting-steps.html
https://helpx.adobe.com/photoshop/kb/troubleshoot-gpu-graphics-card.html
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