Graphics Processor seems to be crashing

While using Photoshop, it seems like the graphics processor will just fail or crash.

Specifically: I use Photoshop to draw and I will nearly constantly be using the R, Space+Ctrl, B, E, X, Ctrl+Z, Ctrl+S, and Caps hotkeys. I will almost never use any other hotkeys.
I will draw for a while and all of a sudden, none of these hotkeys will work (except ctrl+s to save, for some reason). I can't zoom at all, I can't switch tools, I can't use the brush or make marks. The program doesn't seem frozen or "not responding", it's just dead. I close it and restart it and it's fine until the next time it happens. I don't even need to use task manager to close it.

Turning off "use graphics processor" does seem to stop this from happening, but I need this to draw comfortably. It's extremely annoying to draw without it after being so used to it.

I've updated Wacom's drivers and Nvidia's drivers. I've also made sure Photoshop was updated.
Does anyone know what's going on or how I can stop this from happening?

here are my specs
Windows 10 64 bit
Intel i7-6700
32g Ram
Nvidia 1080ti - Studio Driver Version 452.06
Photoshop 21.2.3 (this was happening before I updated to this as well)
Wacom Cintiq 27QHD - Ver 6.3.40-2