Large File Won't Save Ps 2020

I regularly work with large files in Photoshop. They are about 1 square meter and contain many layers. I always use psb and never really have any trouble. I was able to save my design file previously (already beyond 2 gb in size), but when I recently reopened it and made changes it would not save or save as a new file, either in the current location or other locations.
The dialog box warning says that it exceeds 2 gb. Again, it was already a psb file larger than 2 gb so that shouldn't have ever been an issue.
Is there any workaround for this? I feel completely stuck. I could crop and cut layers to reduce file size but they're there for a reason.
