My file has glitched pixels that weren't there before. What could be the cause and is there a fix?

Project is under an NDA so I'm posting a small crop of the damage, but it extends the whole image... When I opened the file it looked normal in the preview, but opened to this. There's a detailed bookshelf in the background that is destroyed, and the foreground has some destruction as well. The pixels are deleted on every layer. Fortunately I have backups but still lost a few hours of work, and this is probably the 3rd time this has happened in a year (to other files). My deadlines are really tight, and this is frustrating.

What could be causing this? I paint in a large .psb format. (7000px by 4000 px). Is there any way to tell if this is just a photoshop-side issue or failing hardware? I've done hardware tests with various programs and none indicate malfunctioning hardware, but I'm not sure if they're testing my harddrives or just the main components.

CPU:  AMD Ryzen 5 1600 CP, GPU: Nvidia geoforce 1060, RAM: 32 GB. Photoshop is run on an internal harddrive.