Photoshop and Indesign freezes when I try to quit

Recently my Photoshop and Indesign have been freezing (rainbow beach ball appears) whenever I try to quit. It just stops and the beach ball appears, and the program stops responding. But it only happens if they have been left open for awhile, or I have made many adjustments. When I open a file, do a simple edit, and close PS, it does close properly.

Any idea what may be causing this? I even used Adobe CC Cleaner to uninstall and reinstall CC, but it is still happening.