Photoshop spinning wheel of death as soon as i open the application.

Hi,

We're sorry about the trouble with Photoshop. Would you mind sharing the exact version of Photoshop you're installed on the computer along with your computers macOS version?

If resetting the preferences, as suggested by thedigitaldog doesn't help, please check if Photoshop has the necessary permissions on your Mac by following the steps suggested below:

1. Go to the System Preferences for your Mac, then Security and Privacy, then select the Privacy tab.

2. Then select Accessibility from the list to the left & check if Photoshop is added to the list with a check mark in front of it.

3. If Photoshop is not a part of the list, please add it by unlocking the window first using the lock at the bottom left, then clicking the + icon & navigating to the Applications folder.

4. Also, grant permissions to Photoshop under Full disk access located in the same list as Accessibility.

5. Once done, restart the Mac & check if it helps.

Let us know how it goes!

Regards,

Nikunj

Try resetting your Photoshop preferences. Press and hold Alt+Control+Shift (Windows) or Option+Command+Shift (Mac OS) immediately after launching Photoshop. You will be prompted to delete the current settings.

(Mac OS only) Open the Preferences folder in the Library folder*, and drag the Adobe Photoshop CS Settings folder to the Trash.

This action only affects the items found in the preferences dialog box. Numerous program settings are stored in the Adobe Photoshop Preferences file, including general display options, file-saving options, performance options, cursor options, transparency options, type options, and options for plug‑ins and scratch disks. Brushes (and lots of other setting) are not affected by the above instructions for deleting preferences. You may wish to make a screen capture of the settings in the Preferences dialog to reset them prior to deleting of this file.

Also: https://helpx.adobe.com/photoshop/using/preferences.html

*To manually delete Photoshop preferences:
Quit Photoshop.
Navigate to Photoshop's Preferences folder:
macOS: Users/[user name]/Library/Preferences/Adobe Photoshop [version] Settings
Windows 10: Users/[user name]/AppData/Roaming/Adobe/Adobe Photoshop [version]/Adobe Photoshop [version] Settings

Note:
The user Library folder is hidden by default on macOS. To access files in the hidden user Library folder, see How to access hidden user library files.
https://helpx.adobe.com/x-productkb/global/access-hidden-user-library-files.html
Drag the entire Adobe Photoshop [Version] Settings folder to the desktop or somewhere safe for a back-up of your settings