Photoshop won't initialize due to scratch discs, but nothing can be done?

I have tried uninstalling and reinstalling.

Opening in special mode to change hard drives and there is no difference.

I have deleted a lot of files to make room.

I have tried first aid.

I have tried to locate ~PST or .tmp files.

I am really struggling I need to work and can't seem to do anything.

HEEEEELLLLLP.

Also my Acrobat keeps asking me to sign in repetitively and I can't make progress there either.

No time left to play. Deadlines await.

Karen.