Preferences file being corrupted

Thanks very much for the responses.  I was pretty stingy with information.  Sorry about that.  The machine I'm running is a Dell M7710M Precision (Mobile) Workstation with 32GB of SDRAM and an Intel Xeon E3-1535M v5 quad core processor.  OS is Windows 10 Pro.  GPU is Nvidia Quadro M5000M w/8GB GDDR5.  Photoshop CC 2018 is set up to use a max of 85%  (24941MB). My C:\, D:\ and M:\ drives are designated as scratch disks.  All are fast SSDs.  History and Cache are set up for Huge Pixel Dimensions because I routinely work with very large files.  According to Device Manager, my GPU is working properly. I have the latest driver.  There is no way I could work w/o  Use Graphics Processor being checked.

[Pause] Actually, your responses prompted me to check the Dell website for driver updates regardless that Windows is saying I have the latest drivers.  The Dell site does have newer drivers.  I'm in the process of installing those.  Perhaps that will help.  Thanks very much for your responses.