Problems with selections and generative fill not finding any pixels

@Angela_Telesca can you post a screenshot of your document with the workspace and layers panel visible?

First thought is you are on a layer mask not a pixel layer.

Hey, @Angela_Telesca. Welcome to the Photoshop Community. I'll help you figure this out.

Please share the screenshot & system info from Photoshop Help > System info > Copy & paste into a text document > upload & attach here.

Before troubleshooting, update Photoshop to the latest version (v25.5.1) via the Creative Cloud desktop app & check if the issue exists. 

I'll move this to discussion for now. Try these steps: 

Ensure there are no stale preferences in your Photoshop. Go to the location of the preference folder below and rename it to backup.

• Windows 10/11: Users/[user name]/AppData/Roaming/Adobe/Adobe Photoshop [version]/Adobe Photoshop [version] Settings
• You can press Press the Windows key > Enter 'Run' > Enter %APPDATA%\Adobe
• Rename the Adobe Photoshop folder by adding a .old at the end. (Adobe Photoshop 2024 > Rename > Adobe Photoshop 2024. old), You can restore these preferences later if needed.(https://adobe.ly/4860qM9)
• Restart the computer.

These changes will give a fresh start to Photoshop as a fresh install. Let me know how it goes.

Thanks!

Sameer K