What is resetting my Photoshop keyboard shortcuts so often Adobe?

There are a few things that might affect what your keyboard shortcuts are. If you switch workspaces, workspaces can include different sets of tools in the toolbar, different keyboard shortcuts etc, in addition to changing the layout of the panels. The other thing that may be happening is if you make changes to Photoshop and it's not shutdown correctly, crashes while using or crashing on quit, any changes to you make to keyboard shortcuts/preferences won't get saved (prefs get saved on quit).