Acrobat Pro 2025 : accès refusé aux disques externes malgré les autorisations macOS

​@Abdou Lazime OUATTARA maybe it’s in a weird loop or something. Open Acrobat’s Preferences (Command K for your MAC), head to the Security (Enhanced) section, and try disabling "Enhanced Security." Hopefully that clears the bottleneck that the System Settings can't reach. 

If you feel confident enough, you could trash your Acrobat preferences. I had changed my MacBook Pro battery, and my Adobe apps were acting up. Apple geniuses had told me to purge my preferences. All of it. I was honestly leery, but glad I did because I feel my Mac is running so much smoothly as before! 

Close all your apps. Library - Preferences - What I did was Command A everything in that folder and copied them into a new folder on the my desktop. I went back to the Preferences folder, Command A to Select All, and Option Delete to take it to the trash. And then Empty that Trash can. Most important is restart your Mac. After it has been restarted, launch Acrobat. It will be forced to rebuild those files from scratch, which usually clears out any "stuck" security flags that were ignoring your manual changes. Just keep in mind this will reset your custom toolbars and view settings too, so you'll have to tweak those back to how you like them.