Can multiple E signatures be applied in one go, to a single Adobe Reader PDF?

You may also want to consider employing a workflow with Adobe Sign for Enterprise, in which case, the best approach would be to use library templates that you can use many times (in the context of adding or changing siganture blocks on the fly, and a flexible way to administer the contract process.

My other observation is that you mentioned about pharmaceutical PDFs.

I assume that by pharmaceutical PDFs you're referring to electronic compliance standards? like HIPAA, FERPA, GLBA, and FDA 21 CFR Part 11 ?

If yes, see some of the features of Adobe Sign for Enterprise: https://acrobat.adobe.com/us/en/sign/business.html

And see here for a brief breakdown of employing certificate-based digital signatures with Adobe Sign: https://acrobat.adobe.com/us/en/sign/digital-signatures.html

Depending on the Adobe Sign plan, one of the main flexible features is that you can assign administrative roles to a group of individuals, or other signers, which may allow one of your signers with an administrative role in a group,  to add other additional signing blocks to a PDF... but I may be wrong.

For this you may need to look into the Adobe Sign Administration guides:

 https://helpx.adobe.com/sign/using/reference-guides.html

Yes, you MUST change your requirement. This is FUNDAMENTALLY broken and will cause you terrible difficulties.

Hi Kate,

Sorry for the delay in response to your question. If you are still looking for the answer for this, then here are some tips and suggestion to accomplish this-

Applying Digital signature on each page of a multi-page document is fundamentally incorrect. Digital Signature always signs the complete document.

Even if you would like to do that, you have to apply signature on each page and save it every time you have been asked after done signing.

Which means, if its 4-page document, applied signature on page-1 then save it. Applied signature on Page-2, save it. applied signature on page-3 save it and so on...

There's no such script of batch process of doing this activity. 

Thanks,

Akanchha