Can't open Acrobat DC and any PDF-File

I have had a similar experience. “File not found” errors when trying to start Acrobat, or even open a PDF file. I get the impression that Windows 10 has done something aggravating to the access permissions of the Acrobat executable and those of PDF files in general. (My background is mainframes and UNIX, so I’m a bit hazy about the Windows security model.)

Anyway, I have found a partial workaround, which at least enables Acrobat to run. Find the executable (Acrobat.exe) which on my system is in “C:\Program Files (x86)\Adobe\Acrobat DC\Acrobat” and copy it to a file in the same directory with a different name, say Acrobat_a.exe. You will need administrator privileges to do this. Make a link to this new file by creating a shortcut on the desktop, and you should find that double-clicking the shortcut will start Acrobat. The file associations won’t work, but at least the program is running.