Have the values in one combo box be filtered based on what went into another combo box

Lets say your dropdown fields names are "Organization" and "Department Address", as Validation script of  "Organization" field use this:

if(event.value == "Org1"){
this.getField("Department Address").clearItems();
this.getField("Department Address").setItems([["100 Washington Street"], ["30 Congress Street"], ["50 State Street"]]);}
else if(event.value == "Org2"){
this.getField("Department Address").clearItems();
this.getField("Department Address").setItems([["200 Franklin Street"], ["450 Gloucester Street"], ["700 Newbury Street"]]);}
else this.getField("Department Address").clearItems();

I belive you will have no trouble adding additional "Org" to the script.

You can also check "Commit selected value immediately" in "Organization" field under properties->options tab.

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