I've created this presentation with latex and it includes an animation. When I run it with Acrobat, the presentation looks blurred, but the first slide opened it always super sharp. When I close the presentation mode and open the reader mode, everything looks sharp on each slide. The problem is that I cannot give the presentation in the reader mode since there's a menu panel at the bottom and the top of the slides. I tried exporting the pdf with Preview to PDF/A and also X3. These indeed show up super sharp in presentation mode but won't load the animation.
If you have a small image and blow it up to a larger size in full screen view, this is expected behavior. Does the image on the first slide have a higher ppi (pixels per inch) than the other images? If so, that would explain why that slide is okay.