Not without using the Flex framework and that requires at
least one mxml file...
<?xml version="1.0" encoding="utf-8"?>
<mx:Application
xmlns:mx="
http://www.adobe.com/2006/mxml"
layout="absolute"
applicationComplete="Main.init()">
</mx:Application>
The 'rest' of the application can be ActionScript only. If
working with data is a major part of the work you must do, this way
you can profit from all the 'extra's' the Flex framework has to
offer, like the powerfull collections and the wrappers for http
requests, remote objects... sheer power. And if your worried about
specific content you can only create in Flash... use the Flash
Component Kit For Flex to bring your Flash content to your Flex
project. It's awesome.