Audition 188.8.131.52 & 184.108.40.206
Pressing CMD+S to save the current file in the Waveform editor does not save the file. A small progress indicator appears and seems to progress, but the Files panel and document tab still display an asterisk after the filename. Morever, attempting to close the file or quit Audition immediately after "saving" with CMD+S prompts the user to save unsaved changes to the file.
First thing to check is the Keyboard Shortcuts to make sure that it's still correctly allocated - it's certainly one you can change...
This started happening again with Audition 2021 (220.127.116.11) on macOS 10.15.7.
I discovered it only happens when Microsoft Word is also running.