Steve, thanks. Great advice.
But I still would like to know the settings that bring the highest quality video output. I don't see recommendations in the Adobe documentation. I assume variable bit rate is better because it produces larger files -- which is fine by me. But not sure about some of the other settings. Any advice on this?
Orson
These are the settings I use when publishing to video. I just cranked everything to ensure I was getting the best quality.

By the way, in earlier versions of Captivate, software simulations were limited to 1280 px. in 2017 you can record in full HD 2k or 4k resolutions.
Check out the Help file on that topic here:
https://helpx.adobe.com/captivate/using/record-software-simulations.html