How can I delete certain files from these Adobe folders to free hard drive space?

I have the macbook pro 15" retina with 500GB flash drive.

I am using Adobe Production Premium CS6 (not CC).

I am running out of space on my drive and noticed that the folder with the path ~/library/application support/adobe is greater than 300GB

Also, in the folder with the path ~/library/preferences/adobe , this folder is >50GB

So, in total, Adobe Production Premium CS6 is using over 350GB (70%) of a 500GB hard drive!!!

How can I delete certain files from these folders to free hard drive space?

I have enclosed a photo of the "get info" of both folders.