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Me too! I'm getting the same error, and I'm running:
- Windows 7 Professional 6.1.7600 (32 bit)
- Internet Explorer 9.0.8112.16421
- Adobe Reader X
I can open Adobe by itself without an error, but when I try to open PDFs on webpages (like any of the PDF maps on this page: http://www.cbe.ab.ca/programs/languages/french1.asp)
it gives me the error above.
Thanks in advance for any help!
I disabled the "Protect Mode" at start up too and now everything is working! 
(W7 Ultimate 64 bits / Adobe Reader XI)
I just started having the same problem. This is a brand new Dell Precision T7600 Workstation with Windows 7 SP1 x64 16MB of memory, Sata hard drives, etc (this is one of the most stable computers ever manufacturered meeting,complying and exceeding ISV-Certified standards) ...
I manage over 200 PC's with similar configurations. I've never seen this particular problem before. It is happening to my customer using Adobe Reader XI (11.0.2). He only uses on his computer Microsoft Office 2010, AutoCad 2012 and Norton Internet Security. They have 19 other identical computers with identical hardware and software configurations. Only one up till now is presenting the problem.
The message is as stated above:
"There is a problem with Adobe Acrobat Reader. If it is running, please exit and try again. (523:523)"
Initially I thought it was an IE10 issue (since it started around the time IE10 was released) but as I've investigated on the web over the last couple of weeks it is also happening on other versions of IE and FireFox, other versions of Windows as well as with other versions of Adobe Reader and Acrobat. The problem seems to be without a doubt an Adobe issue.
What is throwing me off is that I have 18 other computers of the same model with identical software images as the one above. I've tried re-installing Adobe Reader, protected mode "on-off" solutions suggested, downgrading back to IE9, disabling all non-Microsoft startup items and many other suggested fixes (even went to the extreme of removing Norton Internet Security completely just to be thorough). None have worked. My guess is that I will have to wipe out the computer and do a clean install and hope the error does not reappear.
Also, the problem seems to be intermitent. At times it gives the error and once I click on "Ok" it opens the pdf document as if nothing had happened. At other times, closing IE10 and re-opening it solves the problem. Other times re-booting the computer solves it temporarily and other times, just going to another site with pdf files and opening them there and later returning to the website with the problem document allows us to open it without problems.
This behaviour is very erratic. extremely disruptive and annoying to say the least. I'm sorry chief_charlie37, but this seems definitely to be a bug. I'm hoping that Adobe will "listen" and come up with a solution although my experience with Adobe over the years is that they do not even acknowledge issues (I know for a fact, by personal experience of errors and problems that have been annoying customers for years, error that are so persistent that they continue to annoy them trickling down from version to version and seen Adobe just ignore them.
My only advice, to whoever reads this, is to attempt some of the solutions described on a Google search or in this forum. Otherwise, make your voice be heard and post your complaint everywhere you can. It may be the only way to get Adobe's attention.
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