OK,
If you're going to have a commercial printer do the printing, just do a straight PDF and let them do the imposition work to suit their workflow. That's what they're paid for and you're unlikely to have as much experience with their workflow as they do.
If you're looking at in-house or end-user/customer printing, you should use an Acrobat plug-in such as QuiteImposing or any of a number of other plug ins to do the imposition work. But be aware that many times you're going go make choices that aren't supported by a wide variety of printers or printer drivers -- how a printer does double sided, whether the sheet is rotated between passes and other options usually add a big unknown to solving this problem. You can certainly meet the requirements for one particular kind or model of printer, but beyond that, YMMV a lot.