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hi the problem has been resolved.
Im using a Mac Sierra 10.12.6 with a Wacom Intuos pen CTL-480 on Illustrator CC.
Previously the pressure option was greyed out, so I re-installed (upgrade) the Wacom Drive to the newest available, and then I went to (I think it's called) Wacom Utility and removed all users. And I restarted the computer and the greyed out problem was gone.
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As of June 26, 2022 I have the exact same issue and it is not the first time. This has been happening from time to time over the last few years with different versions of Illustrator and MacOs’s. Uninstalling and reinstalling the lastest driver DID help however, just remember that you have to reboot Adobe Illustrator as well for it to load the new drivers. I would prefer for the issue to never arise again however.
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