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Hi everyone! I want to preface this by saying I don't know very much about CMYK / RGB settings in Illustrator. The issue I'm having likely stems from my lack of knowledge vs. Illustrator itself. For those kind enough to give advice, please write as though you're speaking to a beginner. I appreciate your patience as well as your willingness to read and respond to this thread 🙂
Operating System: macOS Monterey Version 12.6
Color Profile:
Illustrator Version: 27.1.1
Color Mode: RGB
Document Settings:
Color Settings:
The issue: 
I'm trying to make Pinterest posts, so I went with RGB as it's best for screens. Throughout my time working on this file, I've noticed the colors change and I don't know why.
I've experienced my original palette lighten:
and become darker / more saturated:
 
Possible Explanations:
– File setup is wrong
– Pasting or embedding photos
– Copying/pasting elements from another Illustrator file with different color settings
– My Mac's color profile doesn't match the one listed in the Illustrator file's color settings
I've read that it's a bad idea to change the color settings of an AI file, so I haven't done that. Does anyone have insight into why this color change might be happening? What can I do to prevent this from happening in the future? Thank you in advance for your help.
The Display profile is probably caused because you Opened an image (with that Display profile) in Illustrator instead of creating a new sRGB document and placing the image. I would create a new document and copy/paste everything from your old into that new document and see how that behaves.
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There have been some general issues with macOS, but that shouldn't apply to your system, it has been isolated to Ventura.
Please set your RGB profile in the color settings to sRGB
Also: please check your Color proof settings - is anything turned on there?
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Monika thank you for your quick response!
I just changed my color settings to sRGB.
As for my color proof settings, it's showing this:
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Can you also check what Edit > Assign Profile shows you?
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Absolutely! Thank you for your quick response, Ton.
 
As per Monika's advice, I changed my color settings to sRGB
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The Display profile is probably caused because you Opened an image (with that Display profile) in Illustrator instead of creating a new sRGB document and placing the image. I would create a new document and copy/paste everything from your old into that new document and see how that behaves.
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Ton, you were right – this is definitely the issue. Thanks so much for your help! I really appreciate it.
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Good to hear we could help.