This is what I got from when I called Wacom Tech Support, hope it helps:
Thank you for contacting Wacom Customer Support. I am sorry that you are having this inconvenience with your tablet. I will be happy to help you. Like we talked, this could be due to some driver or preference file that is outdated or corrupt and it needs to be removed. Please follow the steps outlined below in order to completely remove the current driver and install the latest recommended driver:
First, disconnect the tablet from the computer.
Next, open Finder, then click on Go (at the top of the screen near the Apple menu,) and go to Applications. Locate any Wacom Tablet folder and open the Wacom Tablet Utility in it. Using this utility, please remove all user's preferences and uninstall the driver. (If uninstall is not available, click on the lock icon on the bottom of the window to enable this option. Make sure to create a back up of your preferences first if necessary.)
Restart the computer.
After removing the driver with the utility, please manually check if anything was left behind. Please open Finder, click on Go, and then click on Computer. Once there, please access your main hard drive (by default should be named Macintosh HD) and check if anything is left behind in the folders listed below, delete only the files listed if present:
In Macintosh HD:
Applications/Wacom Tablet
Library/Application Support/Tablet
Library/Frameworks/WacomMultiTouch.framework
Library/Internet Plugins/WacomTabletPlugin.plugin
Library/Launch Agents/com.wacom.wacomtablet.plist
Library/LaunchDaemons/com.wacom.displayhelper.plist
Library/LaunchDaemons/com.wacom.RemoveTabletHelpter.plist
Library/LaunchDaemons/com.wacom.TabletHelper.plist
Library/PreferencePanes/WacomTablet.prefpane
Library/Preferences/Tablet
Library/PriveledgedHelperTools/com.wacom.RemoveTabletHelper
Library/PriveledgedHelperTools/com.wacom.TabletHelper
The same will have to be checked in any respective User’s folder on the system. On OS X 10.7 Lion or later, the User Library folder has been hidden. To access it, you must select 'Go' from the top of Finder and select 'Go to folder...’. Here, enter ~/Library to access the current user's Library folder. Please check for Wacom related files in the Preferences folder and remove them if present:
Users/<your user>/Library/Preferences/com.wacom.ProfessionalTablet.plist
Users/<your user>/Library/Preferences/com.wacom.wacomtablet.prefs
Users/<your user>/Library/Preferences/com.wacom.wacomtouch.prefs
After this is complete then there should not be any leftover files of a previous Wacom driver file.
Restart the computer. When it comes back on, open Finder, go to Applications and then Utilities. Please use the First Aid tool in your Disk Utility to do a repair of your disk permissions.
Now download and install the latest driver from:
http://cdn.wacom.com/u/productsupport/drivers/mac/professional/WacomTablet_6.3.34-2.dmg
Restart the computer.
Once the installation is complete, and the system is stable, connect the tablet to USB. As always, make sure your tablet is connected directly to your computer. Avoid using USB hubs, keyboard/monitor ports, or docking stations with the tablets, as they can cause inconsistent behavior.
I hope the information provided helps. Please do not hesitate to contact me if you require any further assistance, I will be happy to help you.
Thank you for choosing Wacom and have a creative day!
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