Jim,
It may help helpers if you can post a screenshot, upreferably using the Insert Photos button at the top of the Reply box.
- For fixed stroke, you need to have Scale Strokes & Effects turned off.
- Sometimes Illy works in mysterious ways.
If it is happening in just one document it may be corrupted.
Otherwise there may be some other corruption, possibliy temporary.
The following is a general list of things you may try when:
A) The issue is not in a specific file,
B) You have a printer correctly installed, connected, and turned on if it is physical printer. Or you may use Adobe PDF/Acrobat Distiller as the default printer instead.
C) It is not caused by issues with opening a file from external media.
D) It is not caused by other applications (you may close down/disable everything else running, including browsers and antivirus, then try again). There are quite a few usual suspects that may disturb and confuse Illy (job description Adobe Illustrator), and they can make her move in mysterious ways (even more than usual, some would say).
You may have tried/done some of them already; 1) and 2) and 3) are the easy ones for temporary strangenesses, 4), 5) and 6), are specifically aimed at possibly corrupt preferences.
If possible/applicable, you should save current artwork first, of course.
1) Close down Illy and open again;
2) Restart the computer (you may need to do it at least 5 times);
3) Log out of your Adobe account and log back in;
4) Close down Illy and press Ctrl+Alt+Shift/Cmd+Option+Shift during startup (easy but irreversible)
5) Follow the instructions here, you can preserve the preferences as described:
https://helpx.adobe.com/illustrator/using/setting-preferences.html
6) Maybe relevant for older versions Move the folder (follow the link with that name) with Illy closed (more tedious but also more thorough and reversible), for CS3 - CC you may find the folder here:
https://helpx.adobe.com/illustrator/kb/preference-file-location-illustrator.html