RGB Colors Dull in Illustrator

by every measure the new file I created with dull colors is identical to the first file I was working in but my colors dull as well. When I sample the colors, they come out differently. Here are the two screens - on both I sampled the orange in the shape to the right of the cup illustration.:

I had this same issue. Not sure if you ever figured it out, but I went to the top toolbar: View --> Preview on CPU. My colors look vibrant again.

Which color profile is attached to the file?

Which preview option? Does it get better with CPU preview?

What is happening? You create a color and it looks dull immediately? Or does it change over time?