Irregular columns

[Yaroslav34393207mpo1]

How can I create irregular columns with margins like on this screenshot? 
I need that to create a document of leaflet and if you know the paper folding requires different column sizes. I have to create many different leaflet with the same options.
On the first page there would be 3 columns and on the second page would be the same but with mirrored column sizes.

[Steve Werner]

Here's a good article on the issues involved in folding, and give you a good overview of the subject:

https://www.printingforless.com/resources/begin-with-finishing/#:~:text=Compensation.,and%20push%20a...