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I was running LR 6.14 and upgraded to Windows 11. In Library all my images are grayed out, with no error indications. Switching to Develop, I can see and modify the image, but there is no image in the Navigator box. Realizing that LR 6.14 is a little aged, I upgraded to LR 11.5. I get the same results in the Library and Develop Modules. Google searches have provided no resolution.
Lightroom 6 Library
Lightroom 6 Develop 
 
Lightroom 11 Library
 
Lightroom 11 Develop
 
If disabling the GPU doesn't help, a quick way to test for a bad display profile is to assign sRGB temporarily:
If the GPU and display profile aren't causing the problem, then see this help article:
https://helpx.adobe.com/lightroom-classic/kb/lightroom-gives-error-preview-cache.html
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BTW, upgrading to LR 12 does not resolve the problem.
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First, try disabling GPU in the preferences (Performance). Any better?

If not, recalibrate and build a new ICC display profile; the old one might be corrupted. If you are using software/hardware for this task, be sure the software is set to build a matrix, not LUT profile, Version 2, not Version 4 profile.

If turning OFF the GPU works, it's a GPU bug, and you need to contact the manufacturer or find out if there's an updated driver for it.

Also see: https://helpx.adobe.com/lightroom-classic/kb/troubleshoot-gpu.html
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If disabling the GPU doesn't help, a quick way to test for a bad display profile is to assign sRGB temporarily:
If the GPU and display profile aren't causing the problem, then see this help article:
https://helpx.adobe.com/lightroom-classic/kb/lightroom-gives-error-preview-cache.html
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Thank you, John.
Following the instructions at the link for 'change profile to check' my problem resolved and both LR 6 and LR 12 are now working, showing thumbnails.
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Glad you got it resolved.