I have two monitors connected to my PC. Both are connected with display port cables.
One of them is an older 1920x1200 monitor running at 60hz.
The other one is a 4K HDR GSync compatible monitor that runs at 120Hz.
I have an NVidia 1070 video card with the latest drivers, and all Adobe apps are GPU accellerated.
If Lightroom CC is on the old monitor, it works perfectly fine. As soon as I drag it over to the new 4K monitor, the interface lags, it flickers constantly, and becomes completely unusable. However, if I go into the Windows display settings there is a setting for the new monitor "use HDR". If I turn this setting off, then Lightroom CC works absolutely perfectly on the new monitor. The old monitor doesn't have that setting, so HDR is always off on that monitor.
Please update Lightroom CC so that it works properly when it is on an HDR monitor in Windows 10.
I just want to say that this is still a problem on Windows 11. Lightoom CC performance is significantly diminished when the window is on a monitor that has HDR enabled. It's basically unusable. Please fix this.
I have been having some similar issues. For me the issue is with photoshop 2022, I have weird flashing on the screen when I right-click on the canvas. At first, it will work okay and can paint just fine but as soon as I right-click, the menu freezes, my mouse cursor gets stuck on the brush mode when it should be a pointer mouse, and the whole program freezes for a few seconds.
I have a similar setup, running a GTX 1070 with two monitors using DP cables. The older Dell 4k 60hz non-HDR works just fine, but I bought the new Samsung Odyssey G70A 4k 144hz HDR monitor (right now I can only get 120hz, I think it's the cable or card). But as soon as I disable the HDR mode through the Windows 10 settings, it works just fine on both monitors.
I bought this monitor for a new build and I will retest using my new RTX 3080 Ti and see how the performance is. I will also be updating to Windows 11, but I see that did nothing for you Apreche either..