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I'm using Version 21.2.4 and the blending modes don't affect the layer I chose. According to the Undo/Redo command (Edit menu), the action happened but I don't see any change in the photo. I tried clicking Legacy Compositing in Preferences (Performance) and restarting the program but it doesn't change the situation. Color mode is RGB.
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Could you please post screenshots with the pertinent Panels (Toolbar, Layers, Channels, Options Bar, …) visible?
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Blend modes are interactions between layers. There's nothing under this layer, so nothing happens. There's nothing to blend with.
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Just to make sure:
Some people used to recommend duplicating image layers and setting them to Multiply or Screen to darken or brighten the image.
This was not a great approach.
A blank unedited Adjustment Layer set to the Blend Mode would achieve the same result with less data and touch-up on the original image would carry over immediately.
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