Color shift when saving a jpeg

[defaulttti6pugex5w0]

This is a question I see out there on differnet posts, but my problem is with a single psd file. When I save the file it shifts from a red tone to an orange tone - but only this file. All other files hold their original, layered color. (Apologies, I can't show the before/after here, the art is still in a comping phase.) Color settings are the same for all - sRBG etc. 

[Stephen Marsh]

Is the JPEG the same pixel size as the original?

Are you viewing the JPEG and PSD in the same software at 100% view?

Does the image have noise/grain/fine patterns in the area that shifts from red to orange?

[defaulttti6pugex5w0]

Yes, the jpeg is the same size and saved with the sRGB checked on. Yes, viewing the jpeg and PSB in Photoshop - but even in preview the jpeg is washed out, more orange than red. The image does have noise but all of these pieces of art do. I will note there is sky in the uppear left corner that remains pretty close to the layered version, it's the rest of the image that shifts. Note - having a retoucher look at it as well, if he has an answer I'll make sure to post it here.

[Stephen Marsh]

But are you viewing both images at 100% view where 1 image pixel is mapped to 1 monitor/display pixel without interpolation/resampling of fine detail such as noise.